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"In the evaluation of the use of long-term anticoagulant therapy in the management of patients recovered from myocardial infarction, the ultimate criterion" of successful therapy must be a reduction in mortality rate, Richard V. Ebert, MD, of Little Rock, Ark, told the 45th annual session of the American College of Physicians, in Atlantic City, April 6-10.
He cited as "criteria of lesser importance," the reduction in incidence of clinical episodes of myocardial infarction or other complications of the disease which might be influenced by anticoagulant therapy. "The evaluation of therapeutic agents in the treatment of chronic disease is infinitely more difficult than the study of therapy in acute illness."
According to Ebert, a study of survival rates for patients recovered from myocardial infarction showed a progressive decrease in the number of surviving patients over a five-year period as well as a "considerable" difference in the survival of the patients under
Reducing Mortality of Myocardial Infarction Is 'Ultimate Criterion' of Anticoagulant Therapy. JAMA. 1964;188(5):29. doi:10.1001/jama.1964.03060310091041