This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.
Radioactive therapeutic lymphography may best be used prophylactically before detectable metastases occur, according to Edwin J. Liebner, MD, of Chicago, who told the 46th annual meeting of the American Radium Society, in White Sulphur Springs, WVa, April 13-16, that "the primary growth must metast a size in a manner so that intralymphatic therapeutic injection can follow the possible spread of neoplastic cells and be of significant help."
He explained that the technique of injecting radiopaque agents directly into a lymph vessel for diagnostic examinations suggested the feasibility of this method for injecting drugs into the lymph vessels and nodes.
Liebner used radioactive I131 bound to the poppy seed oil (ethiodol) to appraise radioactive lymphography both experimentally and clinically. "The technique of injecting anticancer drugs or radioactive isotopes directly into a lymph vessel must deliver these agents to the lymph node region involved in the spread of cancer." Since lymphography
Uses of Radioactive Lymphography Extended To Therapy As Well As Diagnosis. JAMA. 1964;188(5):33. doi:10.1001/jama.1964.03060310095045