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Clinical Notes
May 18, 1964

Inhibition of Measles Rash by Chickenpox

Author Affiliations

Bethesda, Md

From the US Department of Health, Education, and Welfare, Public Health Serivce, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Clinical Investigations.

JAMA. 1964;188(7):690-691. doi:10.1001/jama.1964.03060330070023

A CASE was recently observed in which measles had onset one week following chickenpox. Surrounding each chickenpox lesion was a zone of normal-appearing skin which never became involved with measles rash. These findings suggested the natural occurrence of a local viral interference phenomenon.

Report of a Case  A 7-year-old boy developed a febrile illness characterized by brightly flushed cheeks and slight malaise, which was followed three days later, on March 31, 1963, by onset of a vesicular rash characteristic of chickenpox. The rash spread maximally within two days and gradually faded in association with recovery from illness.On April 6 febrile illness recurred, this time with considerable prostration, irritation of the eyes, and a dry hacking cough. On April 7 a rash appeared which, by the next day, was typical of measles. At this time (April 8) the crusted healing lesions of chickenpox were surrounded by zones of apparently normal

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