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To the Editor:—
In the discussion on the treatment of schistosomes with stibophen (Fuadin) in the Sept 14, 1963, issue of The Journal (185:874) it is stated that "In adults, total doses of 90 to 100 ml produce cure rates approaching 100%. Treatment should not be interrupted or modified if severe joint and muscle aching develops during the course of therapy; on the other hand, if severe vomiting occurs, therapy should be discontinued for a day or two, and then the dose should be reduced and administered on alternate days for the remainder of the treatment, although the original calculated dose is unchanged." Lest these two sentences should give the wrong impression, I wish to state that (1) stibophen is a dangerous drug; (2) therapy should be discontinued if any toxic signs or symptoms appear, such as aching muscles and joints, or else there is grave danger of an
Malaret GE. Stibophen in the Elimination of Worms. JAMA. 1964;188(8):761. doi:10.1001/jama.1964.03060340059019