Review of six years' experience with regional perfusion in the treatment of melanoma of the limbs reveals a four-year cure rate of 44%. Six of 12 patients treated five years ago have no evidence of malignant disease. Nine of 20 patients with satellitosis or clinically positive inguinal nodes treated four years ago are apparently free of melanoma.
Creech O, Krementz ET. Regional Perfusion in Melanoma of Limbs. JAMA. 1964;188(10):855-858. doi:10.1001/jama.1964.03060360015003