Council on Drugs
June 8, 1964

Enzymes Proposed as Systemic Anti-Inflammatory Agents

JAMA. 1964;188(10):875-876. doi:10.1001/jama.1964.03060360035008

In recent years, a number of enzyme preparations have been proposed for systemic use as supplementary agents in the treatment of soft-tissue injuries. However, the proposed mechanisms of action are entirely theoretical and the clinical evidence offered in support of these claims is insubstantial. There is adequate evidence to show that one enzyme (alpha chymotrypsin), administered intraocularly, facilitates dissection of the lens zonule in intracapsular cataract extraction in adults.