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To the Editor:—
Drs. Platt and Kailin in the issue of Jan 18, 1964 (JAMA187:182) point out the substantially higher sex chromatin frequency in well clinic patients and healthy laboratory workers as compared with that of psychotics, atopic subjects, and persons with chemical reaction syndrome.It is not clear how the authors differentiate between psychosis and "chemical reaction syndrome," nor how the syndrome is established as a clinical entity. It does not appear that the method of diagnosis allows a clear differentiation from psychoneurosis or psychosis. All that has been proved is that certain persons with decreased sex chromatin frequency may react in a rather bizarre manner to a wide range of chemicals normally found in our environment. The reactions could equally well be described as of a psychosomatic nature; the authors have done nothing to prove that a new syndrome exists.
Zavon MR. Sex Chromatin Frequency. JAMA. 1964;188(10):938. doi:10.1001/jama.1964.03060360098029