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The Book Forum
June 29, 1964

Radiation and Radiomimetic Chemicals: Comparative Physiological Effects

Author Affiliations

New Orleans

JAMA. 1964;188(13):1162. doi:10.1001/jama.1964.03060390064030

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Abstract

Knowledge of the effects of ionizing radiations on the physiological processes has been steadily accumulated since Roentgen's discovery. With the evolution of atomic energy, further interest has been stimulated in the effects of radiation on biological systems. Shortly after the splitting of the atom came the discovery that certain types of chemicals can cause biological effects similar to those produced by radiation. The present volume defines the types of chemicals whose biological effects are so similar to those produced by radiation that they have been termed "radiomimetic."

The author carefully compares the physiological effects produced by radiation and certain of these radiomimetic chemicals, such as busulfan (Myleran) and chlorambucil (Leukeran), and discusses in considerable detail the hematological effects of these two categories. Special attention is paid to blood response patterns.

Of the nine chapters presented, five are devoted to hematological aspects, such as relation between effects on growth rate and

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