Over a 71/2-year period, 71 patients with disseminated breast cancer were treated with combined alkylating-agent-corticosteroid therapy. Chlorambucil and prednisolone were the drugs of choice. These agents, administered orally, produced no serious or disagreeable toxic effects. Twenty-four patients (33.8%) had objective regression of six months' duration or longer; average survival time after therapy was 23.9 months. Results are statistically similar to those obtained with sex-steroid and endocrine-ablation therapy, presumably because the three modalities have a similar mechanism of action, ie, suppression and/or eradication of endogenous estrogen.
Freckman HA, Fry HL, Mendez FL, Maurer ER. Chlorambucil-Prednisolone Therapy for Disseminated Breast Carcinoma. JAMA. 1964;189(1):23-26. doi:10.1001/jama.1964.03070010029005