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To the Editor:—
Regarding the report in the March 28, 1964, issue (JAMA187:1030) by H. B. Appelman, "Untoward Reactions to Emulsion Therapy of Pollenosis," it is important to know who gave the emulsion injection in the two reported cases. How much? With what sterile precautions? How was the emulsion prepared?From 1960 to 1961, there were physicians using large single doses of antigens in emulsions and getting severe reactions. However, in the experience of allergists intensively studying repository injections, the incidence of abscesses and anaphylactic reactions in 1963-1964 is practically nil, in no small part due to smaller doses, multiple injections, and specific techniques.
Dickstein B. Repository Therapy. JAMA. 1964;189(2):166. doi:10.1001/jama.1964.03070020094033