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Medical News
August 3, 1964

Rose Bengal Used in Jaundice Identification

JAMA. 1964;189(5):33. doi:10.1001/jama.1964.03070050071049

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Rose bengal labeled with131I is used with a high degree of accuracy to distinguish between surgical and nonsurgical causes of jaundice in a method employed by Robert A. Nordyke, MD, Straub Clinic, Honolulu.

Reporting at the 113th Annual Convention of the American Medical Association in San Francisco in June, Nordyke said the technique permits simultaneous determination of biliary tract patency and quantitation of liver injury. Both sets of data are obtained by scintillation counting external to the body.

Applied to 181 patients, the technique has provided about twice the accuracy of standard liver function tests carried out at the same time, Nordyke said.

Biliary tract function is tested by observing whether131I labeled rose bengal enters the intestine after cholecystokinin is given intravenously in 2 ml of saline over a one-minute period 30 minutes after dye injection.

The scintillation probe, with a wideangle collimator, is placed in

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