Penicilloyl-polylysine was used in an intradermal skin test for the detection of penicillin hypersensitivity in 16,239 patients. In 1,003 patients with history of penicillin sensitivity, 396 had a positive skin test compared to a positive test in 775 of 12,559 patients with a negative history. Penicillin was administered to 13,530 patients with a negative skin test, of whom 63 had a reaction. Of 212 patients with a moderately positive and 206 with a strongly positive skin test who were given penicillin, 9 and 21 respectively experienced reactions. No anaphylaxis or life-threatening reactions occurred in patients with negative skin tests, although on the basis of previous experience this number of cases should have produced four reactions severe enough to require hospitalization.
Brown BC, Price EV, Moore MB. Penicilloyl-Polylysine as an Intradermal Test of Penicillin Sensitivity. JAMA. 1964;189(8):599-604. doi:10.1001/jama.1964.03070080005001