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Clinical Notes
August 24, 1964

Podophyllum Resin Poisoning With Complete Recovery

Author Affiliations

Toledo, Ohio

Dr. Balucani is resident in obstetrics and gynecology, and Mr. Zellers is director of pharmacy services at Maumee Valley Hospital.

JAMA. 1964;189(8):639-640. doi:10.1001/jama.1964.03070080045017

A REVIEW of the literature of podophyllum resin poisoning revealed only four cases, of which three were fatal and the fourth involved neurological sequelae. It appears worthwhile to report our case because of the complete recovery of our patient.

Report of a Case  A 19-year-old white female was admitted to the hospital on Jan 18, 1964, with complaints of urinary frequency and burning at the micturition. Her last normal menses was on June 24, 1963. Her history was not contributory.Physical examination revealed a well-developed, well-nourished woman in no acute distress. Eyes, nose, throat, and chest wall were normal. The breasts were enlarged, with dark pigmentation of the areolae. The lungs were clear to auscultation and percussion. The heart examination did not reveal any murmur or enlargement. The blood pressure was 120/60 mm Hg; the pulse rate was 82 beats per minute, rhythmic and regular.The abdomen was enlarged as

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