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August 24, 1964

Porphyria Cutanea Tarda and Chloracne

Author Affiliations


JAMA. 1964;189(8):646. doi:10.1001/jama.1964.03070080052025

To the Editor:—  An editorial with the above title, appearing in The Journal for July 6, 1964 (189:56), was based on a paper published by Bleiberg et al (Arch Derm [Chicago] 89:793 [June] 1964). This was entitled "Industrially Acquired Porphyria" and described the association of porphyria cutanea tarda (PCT) and chloracne in individuals engaged in the synthesis of 2,4 di- and 2,4,5 trichlorphenols. These substances are related to hexachlorobenzene, the established cause of an epidemic of hepatic cutaneous porphyria in Turkey1 and of experimental hepatic porphyria in rats2In both the editorial and the paper of Bleiberg and co-workers there is an unfortunate confusion with respect to the use and significance of chemical diagnostic methods in cases of PCT, especially the acquired form due to chlorinated benzene ring compounds, as mentioned above. The editorial states: "Overt cases are readily diagnosed clinically, and by examination of the

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