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August 31, 1964

Cutaneous Manifestations Of Autoimmune Disease

JAMA. 1964;189(9):38. doi:10.1001/jama.1964.03070090070043

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Abstract

Dermatomyositis, polyarteritis, scleroderma, and other primarily cutaneous disorders have shown manifestations of autoimmunity; however, not all of the "markers" of the autoimmune disease process have been demonstrated, J. Lamar Callaway, MD, Durham, NC, reported to a symposium on skin and systemic disease, Washington, DC.

"When one considers diseases such as psoriasis, dermatomyositis, scleroderma, polyarteritis nodosa, systemic lupus erythematosus (SLE), pemphigus, pyoderma gangrenosum, and 'eczema,' the absence of a specific etiologic agent makes the autoimmune concept enticing—and some similarities between those of the more classic autoimmune diseases, such as rheumatoid arthritis, makes this possibility more feasible," Callaway told physicians at the meeting sponsored by the National Medical Association and the American Medical Association.

In SLE alterations in the biochemical indices, fibroid degeneration of collagen and intracellular tissues, infiltration of cellular tissues with lymphocytes and plasma cells, diffuse vasculitis, nuclear degradation, and response to corticosteroid therapy suggest autoimmune disease, according to Callaway

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