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Original Contributions
September 21, 1964

Retrospective Serologic Diagnosis of Hemolytic Transfusion Reactions

Author Affiliations


Dr. Yunis is associate professor and director of blood bank, Department of Laboratory Medicine. Miss Benson is principal medical technologist of the blood bank, University of Minnesota School of Medicine.

JAMA. 1964;189(12):907-910. doi:10.1001/jama.1964.03070120029007

The measurement of antibody titers at different intervals following blood transfusion reactions provides a useful method of investigating blood incompatibility in patients when the pretransfusion blood samples of the donor and recipient are not available. The anamnestic response of an iso-antibody following transfusion is presumptive evidence of a blood transfusion reaction due to blood group incompatibility.