The measurement of antibody titers at different intervals following blood transfusion reactions provides a useful method of investigating blood incompatibility in patients when the pretransfusion blood samples of the donor and recipient are not available. The anamnestic response of an iso-antibody following transfusion is presumptive evidence of a blood transfusion reaction due to blood group incompatibility.
Yunis EJ, Ziegler N, Benson S. Retrospective Serologic Diagnosis of Hemolytic Transfusion Reactions. JAMA. 1964;189(12):907-910. doi:10.1001/jama.1964.03070120029007