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Original Contributions
October 5, 1964

Methicillin Tolerance After Penicillin G Anaphylaxis

Author Affiliations


From the Medical Service, Veterans Administration Hospital, and the University of Tennessee, College of Medicine.

JAMA. 1964;190(1):39-40. doi:10.1001/jama.1964.03070140045005

Eight consecutive patients with histories of penicillin G anaphylaxis have been given the usual dose (1 gm) of sodium methicillin without any reaction. Immediate type skin testing to aqueous potassium penicillin G has been positive in each patient, and sodium methicillin (Staphcillin) tests have been negative except for a nonspecific irritant reaction when high concentrations have been used.