October 5, 1964

Safety of Dyclonine

Author Affiliations

New Orleans

JAMA. 1964;190(1):80. doi:10.1001/jama.1964.03070140086026

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To the Editor:—  The phrases which Dr. Merifield has quoted out of context certainly create the impression that we regard dyclonine to be free of reactions, but the first two sentences of the same paragraph indicate otherwise. We state that "No ideal drug... is available," and that dyclonine is "relatively safe." The discussion, therefore, adequately conveys our belief that reactions are possible. Our goal was to stress comparative potency and efficacy rather than toxicity. We indicated that the seven or eight most effective drugs are among the more toxic systemically, with the exception of dyclonine, which has a low systemic toxicity.We are familiar with Dr. Merifield's excellent report on his experiences with dyclonine. He found, as we did, that the 1% solution is more effective than the more dilute solutions. We have seen no convulsions with the drug, despite the fact that some staff members utilize the contents of

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