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Studies of the addictiveness of an analgesic, cyclazocine, which is 40 times as potent as morphine, have been conducted at the National Institute of Mental Health Addiction Research Center, Lexington, Ky.
Findings were reported at the meeting of the American Society for Pharmacology and Experimental Therapeutics, Lawrence, Kan, by W. R. Martin, MD, director of the center; H. F. Fraser, MD; C. W. Gorodetzky, MD; and D. E. Rosenberg, MD.
A dose of.25 mg of cyclazocine produces the same amount of pain relief as 10 mg of morphine, according to Louis Lasagna, MD, and John Pearson, MD, both of Johns Hopkins Medical School, Baltimore, who evaluated the effects on postoperative pain.
"In animals the drug acts as a narcotic antagonist," Lasagna said. "The possible combination of a powerful analgesic with a narcotic antagonist is exciting."
Analgesic Appears More Potent, Less Addictive Than Morphine. JAMA. 1964;190(2):37. doi:10.1001/jama.1964.03070150105057