[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.146.176.35. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Original Contributions
October 19, 1964

Spectrophotometric Analysis of Amniotic Fluid in Erythroblastosis Fetalis

Author Affiliations

Philadelphia

From Temple University Hospital and School of Medicine.

JAMA. 1964;190(3):195-198. doi:10.1001/jama.1964.03070160019004
Abstract

Spectral absorption curves were plotted on amniotic fluid specimens from 38 Rhsensitized patients and one ABO-sensitized patient. Height of the 450-mμ peak gives reliable prediction of the severity of the hemolytic process of the fetus: peaks of 5 units or less were associated with infants who showed only minimal or no evidence of hemolytic disease; peaks greater than 5 units were associated with increasing hemolytic disease. Amniocentesis was found to be a safe valuable prenatal procedure, an aid to the physician in determining which patients require early delivery (thereby reducing mortality from erythroblastosis) and which can go to term (thereby eliminating complications which might arise from early induction of labor).

×