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Original Contributions
November 2, 1964

Apnea With Intramuscular Colistin Therapy

Author Affiliations

Columbus, Ohio

From the Department of Medicine, School of Medicine, Ohio State University.

JAMA. 1964;190(5):421-424. doi:10.1001/jama.1964.03070180019004

Apnea, attributed to sodium colistimethate therapy, occurred in a 50-year-old Negro male. Sufficient evidence now exists to confirm that colistimethate may be neurotoxic in humans. Awareness of potential colistimethate toxicity may dictate added caution in treating infections in patients with chronic debilitating diseases, chronic renal disease, hypoxic states, or those receiving muscle relaxants, adrenocorticosteroids, sedatives, narcotics, or anesthetic agents.