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Studies with amantadine hydrochloride indicate that prophylactic activity of such chemicals against virus diseases is possible and enhances the outlook for chemotherapy in the treatment of systemic virus disease, C. E. Hoffmann, MD, E. I. du Pont de Nemours Laboratories, Wilmington, Del, told participants at the fourth Interscience Conference on Antimicrobial Agents and Chemotherapy."Although the mode of action is prophylactic with respect to infections of single cells, significant antiviral activity is demonstrated with treatment started late in the disease process of mice and tissues infected with influenza virus," Hoffmann said.Within the past two years, the anti-influenza activity of amantadine has shown prophylactic activity in challenge studies in humans with an attenuated influenza virus and in a natural influenza in man, he said.After significant antiviral activity was clearly demonstrated in animal infections, Hoffmann explained, modeof-action studies were undertaken. In studies with influenza type A virus infections
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