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Original Contributions
November 23, 1964

Urea-Creatinine Ratio in Obstructive Uropathy and Renal Hypertension

Author Affiliations

San Francisco

From the Division of Urology, Department of Surgery, University of California School of Medicine.

JAMA. 1964;190(8):719-720. doi:10.1001/jama.1964.03070210025004

An elevated ratio of blood urea nitrogen to serum creatinine was found in patients with severe urinary tract obstruction, and a lower ratio of urinary urea to creatinine was found in cases of renal ischemia. These findings are believed to be secondary, for the most part, to the slowing of the flow of urine through the renal tubule, with a resultant greater reabsorption of urea; this slowing, with obstruction, is from hydrostatic back pressure and, with renal ischemia, from a decrease in glomerular filtration rate. These ratios may be of practical value both in determining the relative role of obstruction in cases of impaired renal function and in differential function studies for renal hypertension.