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A follow-up study of 146 patients with tuberculosis, who were resistant to isoniazid and were treated with combinations of drugs to which their organisms were susceptible, indicates that 81 of the 96 surviving patients have remained consistently culture negative, it was reported at the fourth Interscience Conference on Antimicrobial Agents and Chemotherapy.
From Jan 1, 1960 to Dec 31, 1962, 146 patients excreting tubercle bacilli resistant to isoniazid were retreated for at least 120 days with simultaneous administration of three drugs indicated by pretreatment susceptibility tests, anticipated toxicity, and previous results of drug therapy, according to D. A. Fischer, MD, National Jewish Hospital, Denver. The patients were followed for an average of 29 months.
Retreatment regimens included kanamycin sulfate, ethionamide, and either cycloserine or pyrazinamide. Other drugs used less frequently were viomycin sulfate, capreomycin, ethambutol hydrochloride, and diisoamyloxythiocarbanilide in various combinations.
Most patients in the study had advanced cavitary tuberculosis.
Retreatment of 146 Tubercular Patients Analyzed. JAMA. 1964;190(8):35. doi:10.1001/jama.1964.03070210115049