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Lab Reports
June 6, 2012

Enhancing Antibiotic Treatments

JAMA. 2012;307(21):2247. doi:10.1001/jama.2012.5727

Certain host factors called specialized proresolving mediators (SPMs) are important for clearing bacterial infections and may help lower antibiotic requirements, reports a research team led by investigators in Boston (Chiang N et al. Nature. 2012;484[7395]:524-528). The dominant SPMs (which are anti-inflammatory lipid derivatives) identified were resolvin D5 (RvD5) and protectin D1 (PD1).

In mice with Escherichia coli infections, SPMs lessened infection-related symptoms, increased clearance of infectious bacteria, and improved survival rates. Administering the antibiotic ciprofloxacin together with SPMs accelerated the resolution of infections more than giving either SPMs or antibiotics alone.

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