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June 6, 2012

Vitamin D Therapy and Cardiac Function in Chronic Kidney Disease

Author Affiliations

Author Affiliation: Department of Internal Medicine-Nephrology, Patras University Hospital, Patras, Greece (

JAMA. 2012;307(21):2253. doi:10.1001/jama.2012.4168

To the Editor: The Paricalcitol Capsule Benefits in Renal Failure-Induced Cardiac Morbidity (PRIMO) trial by Dr Thadhani and colleagues1 failed to show any improvement in left ventricular mass index (LVMI) in patients with chronic kidney disease (CKD) after daily oral administration of paricalcitol for 48 weeks. Similar outcomes have been reported in other prospective studies of patients with CKD receiving erythropoiesis-stimulating agents.2,3

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