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March 2, 1963

Evaluation of Ephedrine Test

Author Affiliations

Columbus, Ohio; Lexington, Ky.

Professor and Director, Department of Anesthesiology, The Ohio State University (Dr. Hamelberg).; Professor and Chairman, Department of Anesthesia, The University of Kentucky (Dr. Bosomworth).

JAMA. 1963;183(9):782-783. doi:10.1001/jama.1963.63700090028016

RESERPINE, guanethidine sulfate, and some tranquilizers are known to modify the neuroeffector action of levarterenol bitartrate in animals.1, 2 This fact and clinical experience have led anesthesiologists to recommend that elective operations be postponed until 2 or 3 weeks after therapy with these drugs has been discontinued. Recently Crandell3 introduced the "ephedrine response test" to more accurately predict the time when patients receiving resperine would be suitable candidates for elective operation. This report presents our clinical findings concerning this test when used as a screening test to predict the occurrence of hypotension during anesthesia in patients receiving known or unknown antihypertensive or tranquilizing drugs.


Ephedrine Test.  —With the patients in the supine position three baseline BP and pulse rate readings were obtained. Using a slightly different dosage schedule from that presented by Crandell, we gave our patients 5 mg of ephedrine sulfate intravenously. During the next

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