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March 2, 1963


JAMA. 1963;183(9):804. doi:10.1001/jama.1963.03700090124022

Whooping Cough.  —Julien Marie and Mme. F. Herzog presented, at the meeting of the National Academy of Medicine, on Jan 5, 1962, a method of detection of fluorescent antibodies for an early diagnosis of whooping cough. The authors examined 75 patients. They found 39 carriers of authentic whooping cough. Of these, 31 were diagnosed by the method of fluorescent antibodies; 28 were positive. At the catarrhal stage, this technique was positive 12 times out of 12. On the other hand, it is very difficult to diagnose the disease at that stage by seeding Flügge droplets on a culture of Bordet-Gengou. The method of fluorescent antibodies gave positive results 7 times in 7 cases during the first week of paroxysmal cough. However, after the first week of paroxysms, the method encountered failures, which, according to the authors, are due to the fact that fluorescence of Bordet-Gengou bacilli decreases considerably after antibiotic

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