A longitudinal study of the nasal carriage of coagulase-positive staphylococci among 373 children from a rural county revealed that 118 (32%) children never harbored such organisms over an 8-mo period. Sixty-four (17%) of the children were found to be persistent carriers. There was no measurable dissemination of staphylococci from the hospital to the community group under study. Staphylococci of phage type 80/81 were found to constitute only 6% of all strains isolated. Sharp increases in the incidence of penicillin-resistant strains were encountered after the administration of antibiotics to these children. The acquisition rate of new strains increased from 6.7% to 13.3% after antibiotic therapy. Carriers of penicillin-sensitive strains were seen most frequently to acquire new sensitive strains, whereas carriers of resistant strains most frequently acquired new resistant strains.
Page MI, Van Zandt Hawn C, Cannon JH. The Nasal Carriage of Staphylococci Among Children of a Rural Community. JAMA. 1963;183(13):1063-1067. doi:10.1001/jama.1963.03700130031007