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February 23, 1963

ESTROGENS IN THE TREATMENT OF ATHEROSCLEROSIS

JAMA. 1963;183(8):682. doi:10.1001/jama.1963.03700080090019
Abstract

In this issue a report (p 632) is presented on the effects of estrogens in men under 50 years of age who have had a myocardial infarction. The estrogens employed were in the form of the natural hormones, mixed conjugated equine estrogens (Premarin). The sole criterion used to evaluate their beneficial effect was the five-year rate of survival of men so treated as compared with a matched group given a placebo. It was found that a statistically significant augmentation of survival rate (approximately 50% at the end of five years of therapy) was obtained with the estrogen preparation when administered over a long-term period in a dosage of 10 mg per day orally. This was accompanied by an alteration in the blood lipoprotein-lipid pattern. The large dosage led to breast enlargement and loss of libido and potency. No other significant unwanted effects were noted when estrogen therapy was begun three

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