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February 23, 1963

Rhesus and MN Blood Types

JAMA. 1963;183(8):714. doi:10.1001/jama.1963.03700080122034

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To the Editor:  —Statistically significant evidence of associations between duodenal and gastric ulcer, gastric carcinoma, rheumatic fever, and the Rhesus and MN blood groups has been reported (JAMA179:479-485 [Feb 17] 1962). The frequency of the R1R2 presumptive genotype was found to be significantly increased in patients with gastric carcinoma and duodenal and gastric ulcer, and the R2r, (r'r")r and NN genotypes in patients with rheumatic fever; the frequency of the R1R1 and R2r presumptive genotypes was significantly reduced in patients with gastric carcinoma. Clarke et al (Brit Med J1:1734-1736 [June 23] 1962) suggested that these findings might indicate a "transfusion effect" rather than a cause-and-effect association between the diseases and blood groups.Our data on patients with duodenal and gastric ulcer have been reevaluated by dividing the patients into (A) those who had received blood transfusions 90 days or less prior to the typing done for

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