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February 23, 1963

Carcinogenic Activity of Cigarette Smoke Condensate

JAMA. 1963;183(8):716-717. doi:10.1001/jama.1963.03700080123039

To the Editor:  —Despite many disadvantages the value of using experimental animals to investigate various human diseases is evident. Dr. Needles apparently is unaware of the extent of the research into the human lung cancer-cigarette problem. The use of the entire respiratory membrane of the human in his calculations is not consistent with observations that smoke particles are not evenly distributed1 2 throughout the bronchi and alveoli but localize on relatively small areas mainly at the divisions of the major bronchi. It has been estimated that the ratio of areas of experimental mouse skin to the human bronchial mucosa effectively exposed to cigarette smoke is 1 to 6.2 In our experiments, the total amount of smoke tar painted on each mouse during the year which comprised the experiment was less than 50 gm. A heavy smoker may inhale 200 to 400 gm of smoke tar each year for

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