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April 21, 1962

Influenza Vaccination

JAMA. 1962;180(3):263. doi:10.1001/jama.1962.03050160079029

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To the Editor:—  I note in your Editorial on Influenza Vaccination (JAMA178:656 [Nov. 11] 1961) that no mention is made of the intracutaneous administration of 0.1 ml. of vaccine as an alternative to the subcutaneous administration of 1 ml. of vaccine where there was a shortage of supply of vaccine and also where the administration of the full 1 ml. dose in severely debilitated persons might be harmful to their condition if a constitutional reaction resulted.In The Journal (165:356 [Sept. 28] 1957) the Special Committee on Influenza stated that the intracutaneous administration of 0.1 ml. of vaccine may be used in lieu of the subcutaneous administration of 1 ml., though the latter was preferable.In The Journal (165:278 [Sept. 21] 1957), under "Correspondence," Dr. Louis Tuft, who first introduced the intracutaneous method of immunization, states that the smaller intracutaneous dose (0.1 ml.) will induce a

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