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May 19, 1962

Measurements of Exocrine and Endocrine Functions of the Pancreas

JAMA. 1962;180(7):636. doi:10.1001/jama.1962.03050200120026

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This book comprises the edited proceedings of a seminar held under the auspices of the Association of Clinical Scientists. As the editors indicate, it was intended to focus on problems of methodology, and also to encompass fundamental chemical considerations and clinical interpretations. In the opinion of the reviewer, the intention has been successful in the former but has failed in the latter.

The first section, on the exocrine functions of the pancreas, offers admirable critiques of the various enzymatic methods available for measurement of amylase and lipase activities. The measurement of the trypsin inhibiting capacity of serum remains of doubtful usefulness, to judge by its empirical correlation with disease states of the pancreas.

The references are among the most valuable dividends of the book. One discrepancy is the perpetuation of the idea that there is a specific collagenase in pancreatic juice, without considering the data of Lewis et al. (J

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