Letters Section Editor: Stephen J. Lurie,
MD, PhD, Senior Editor.
To the Editor: In their Grand Rounds article
about nonalcoholic fatty liver disease (NAFLD), Drs Clark and Diehl1 stated that advanced disease, including cirrhosis,
may not be detectable by either serum aminotransferases or diagnostic imaging.
Although they emphasized the importance of liver biopsy to detect NAFLD, we
believe that this conclusion is premature.
Yanai H, Morimoto M. Diagnosis of Nonalcoholic Fatty Liver Disease. JAMA. 2003;290(12):1577. doi:10.1001/jama.290.12.1577-a