Author Affiliations: Department of Otolaryngology, Taipei Medical University Hospital, Taipei, Taiwan (firstname.lastname@example.org).
To the Editor: Dr Garbutt and colleagues reported the results of a randomized, placebo-controlled trial of adults with rhinosinusitis comparing a 10-day course of amoxicillin (1500 mg/d) with placebo administered in 3 doses per day.1 They concluded that the 10-day course of amoxicillin did not reduce symptoms after day 3 of treatment compared with placebo. However, the study has methodological limitations.
Sun C, Hsu H, Hung S. Acute Rhinosinusitis Treatment. JAMA. 2012;307(22):2368. doi:10.1001/jama.2012.4389