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June 13, 2012

Acute Rhinosinusitis Treatment

Author Affiliations

Author Affiliations: Department of Otolaryngology, Taipei Medical University Hospital, Taipei, Taiwan (seedturtle@gmail.com).

JAMA. 2012;307(22):2368. doi:10.1001/jama.2012.4389

To the Editor: Dr Garbutt and colleagues reported the results of a randomized, placebo-controlled trial of adults with rhinosinusitis comparing a 10-day course of amoxicillin (1500 mg/d) with placebo administered in 3 doses per day.1 They concluded that the 10-day course of amoxicillin did not reduce symptoms after day 3 of treatment compared with placebo. However, the study has methodological limitations.

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