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July 18, 2012

Retinal Detachment and Fluoroquinolones

Author Affiliations

Letters Section Editor: Jody W. Zylke, MD, Senior Editor.

Author Affiliation: Poostchi Ophthalmology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran (norozzadeh@gmail.com).

JAMA. 2012;308(3):233. doi:10.1001/jama.2012.6630

To the Editor: Dr Etminan and colleagues1 demonstrated that current users of oral fluoroquinolones were at higher risk to be diagnosed with retinal detachment than nonusers. The authors discussed the limitations of the study, but 2 other issues may affect interpretation of the results.

First, the authors stated that “The risk of retinal detachment from our study was only elevated among current users but not among recent or past users, indicating an acute adverse event.”1 Table 3 of the article showed that the numbers of patients with retinal detachment and fluoroquinolone use were 145, 12, and 288 in current, recent, and past users, respectively. Although the sample sizes in the current and past users subgroups seem adequate, enrollment of only 12 patients in the recent use subgroup raises concern about the power of the study to detect an association. Providing information about the power of the study to detect statistically significant associations would be beneficial.

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