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Global Health
July 18, 2012

Anti–HIV-1 Antibodies

JAMA. 2012;308(3):227. doi:10.1001/jama.2012.8390

Two antibodies that neutralize HIV-1 have been isolated from human breast milk, a finding that helps explain why only 1 in 10 mothers infected with HIV-1 pass on the virus to their breastfeeding infants (Friedman J et al. PLoS One. 2012;7[5]:e37648).

Researchers from Duke University, Durham, NC, isolated the antibodies from mucosal B cells in the colostrum of a lactating woman from Malawi who was infected with HIV-1. The HIV-1 envelope–specific antibodies—CH07 and CH08—are 2 of the first anti-HIV antibodies to be found in a mucosal compartment and the first to be isolated from colostrum.

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