Young men and adolescents being treated with antiretroviral therapy (ART) for HIV have lower bone mass than HIV-negative controls of the same age group, according to a study funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development.
Low bone mass is a common issue for patients with HIV and has been associated with ART use, inflammation, hepatitis B or C coinfection, and lifestyle factors such as smoking and alcohol use. Because peak bone mass occurs during adolescence, the authors note that low bone mass during this period is particularly worrisome because it may increase the risk of fracture later in life.
Kuehn BM. HIV and Bone Mass. JAMA. 2012;308(4):331. doi:10.1001/jama.2012.8437