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February 1, 2012

Prostate Cancer Risk and Vitamin E—Reply

Author Affiliations

Letters Section Editor: Jody W. Zylke, MD, Senior Editor.

Author Affiliation: Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio (kleine@ccf.org).

JAMA. 2012;307(5):453-454. doi:10.1001/jama.2012.56

In Reply: The correspondents both address the biological mechanisms underlying the results of SELECT. Dr Gaby raises an interesting hypothesis about the interaction between α- and γ-tocopherol, which the SELECT authors hope to address using the biorepository of plasma samples by measuring levels of the different forms of vitamin E at baseline and after intervention in a subset of participants. Dr Hoskote and colleagues hypothesize that the placebo used in SELECT may protect against prostate cancer. The vitamin E placebo used was composed of soybean oil, predominantly polyunsaturated fatty acids. To my knowledge, the effect of soybean oil on risk of prostate cancer has never been tested in humans.

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