Letters Section Editor: Jody W. Zylke, MD, Senior Editor.
Author Affiliations: Department of Pneumology, Medizinische Hochschule Hannover, Hannover, Germany (Dr Welte; email@example.com); Department of Anesthesiology and Intensive Care Medicine, Friedrich-Schiller University, Jena, Germany (Dr Brunkhorst); and Clinical Trial Center Leipzig, University of Leipzig, Leipzig, Germany (Ms Kuhnt).
In Reply: Both Dr Rodríguez-Baño and Dr Du and colleagues raise similar concerns that the treatment options of meropenem monotherapy vs meropenem plus moxifloxacin used in our study appear to contradict current guidelines for the treatment of severe community-acquired pneumonia, which recommend a combination of a β-lactam and a macrolide or an antipseudomonal β-lactam combined with an aminoglycoside or ciprofloxacin in cases of suspected Pseudomonas infection.1 While we agree with these recommendations for treating pneumonia, our study focused on patients with severe sepsis and septic shock independent of the focus of infection.
Welte T, Brunkhorst F, Kuhnt E. Treatment of Sepsis-Related Organ Dysfunction—Reply. JAMA. 2012;308(12):1206-1207. doi:10.1001/2012.jama.11271