Expression of EPHA4, a receptor previously shown to influence axon growth, was inversely correlated with late disease onset and survival in 158 Dutch patients with amyotrophic lateral sclerosis (ALS), report investigators from Belgium (Van Hoecke A et al. Nat Med. doi:10.1038/nm.2901 [published online August 26, 2012]). EPHA4 binds to ephrins, proteins thought to play a role in synapse formation and regulation of long-term synaptic plasticity and memory.
Hampton T. Potential Target for ALS Therapy. JAMA. 2012;308(13):1310. doi:10.1001/jama.2012.13154