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Editorial
October 17, 2012

Lynch Syndrome in Patients With Colorectal CancerFinding the Needle in the Haystack

Author Affiliations

Author Affiliations: Gastrointestinal Cancer Prevention Program and Clinical Cancer Genetics Program, Department of Medicine, Stanford University School of Medicine, Stanford, California.

JAMA. 2012;308(15):1581-1583. doi:10.1001/jama.2012.14171

Identification of individuals at increased risk of hereditary cancer allows for the possibility of screening and early cancer detection, possibly resulting in decreased disease-specific mortality, and is the justification for germline genetic testing for specific cancer risk alleles. However, factors of prevalence and age-specific penetrance, effectiveness and invasiveness of screening procedures, and efficacy of early detection influence the potential benefit of such an approach.

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