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Article
December 1, 1962

Negative Results

JAMA. 1962;182(9):937. doi:10.1001/jama.1962.03050480043010
Abstract

Phenobarbital 

Its Effect on Learning in Epileptic Children  Irwin Wapner, EdD, Don L. Thurston, MD, and Jean Holowach, MD, St. LouisTHE INTELLIGENCE of epileptics has been reported on by a number of authors, but their learning ability has not been adequately investigated. The present study was designed to observe changes in learning behavior and intellect when phenobarbital was initially introduced.Lennox1 reporting on the mental progress of epileptic patients on a variety of medications, including phenobarbital, bromides, and patent medicines, indicated that the group taking phenobarbital showed the greatest progress. He did not attribute this improvement directly to the phenobarbital, but rather to the diminution of seizures. Somerfeld-Ziskind and Ziskind2 reported that phenobarbital had no detrimental effect on the intellect of their experimental group and actually reported a slight increase in I.Q. among the younger subjects during the first year of medication. Barnes and Fetterman3 report

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