Author Affiliations: Duke University Medical Center, Durham, North Carolina (Drs Califf and Sanderson); School of Natural Resources and Environment, Department of Pediatrics, University of Michigan, Ann Arbor (Dr Miranda); Duke Translational Medicine Institute, Durham (Dr Califf); and Duke Health Technology Solutions, Durham (Dr Sanderson).
Substantial age-adjusted reductions in cardiovascular mortality and morbidity over the past few decades are being challenged by increases in physical inactivity, diabetes mellitus, and obesity, creating a large and aging population with long-term cardiovascular disease (CVD). However, the US national investments in discovery and translational science1 continue to produce major advances, both in understanding these conditions at the cellular level and in development of therapeutic and diagnostic tools that can improve health outcomes.
Califf RM, Sanderson I, Miranda ML. The Future of Cardiovascular Clinical ResearchInformatics, Clinical Investigators, and Community Engagement. JAMA. 2012;308(17):1747-1748. doi:10.1001/jama.2012.28745