A new inhibitor can help previously nicotine-addicted rats avoid relapse. Researchers from the University of Toronto found that long-term nicotine exposure causes 2 ligand-gated ion channels—α7 nicotinic acetylcholine receptors (α7nAChRs) and NMDA glutamate receptors (NMDARs)—to interact and form a protein complex in the brain and that this interaction can be disrupted by an inhibitor (Li S et al. J Exp Med. doi: 10.1084/jem.20121270 [published online October 22, 2012]).
Hampton T. Help for Ex-Smokers?. JAMA. 2012;308(22):2326. doi:10.1001/jama.2012.111754