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December 26, 2012

Markers for Prediction of Cardiovascular Disease Risk

Author Affiliations

Author Affiliations: Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands (

JAMA. 2012;308(24):2561-2562. doi:10.1001/jama.2012.25786

To the Editor: The article by Dr Yeboah and colleagues1 compared the ability of several risk markers to improve prediction of coronary heart disease (CHD) and cardiovascular disease (CVD) among individuals at intermediate risk. The authors reported that coronary artery calcium (CAC) provided superior reclassification compared with other risk markers and recommended CAC as a tool for refining cardiovascular risk prediction in individuals at intermediate risk. While the added predictive ability of CAC in CHD risk prediction was substantial and confirmed previous findings,2 we believe that supporting CAC as a candidate for CVD screening based on the results is less grounded.

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