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January 2, 2013

Omega-3 Fatty Acid Supplementation and Cardiovascular Disease Events

Author Affiliations

Letters Section Editor: Jody W. Zylke, MD, Senior Editor.

Author Affiliations: Department of Pharmacological and Biomolecular Sciences, Università di Milano, Milan, Italy (Dr Galli); and Division of Nutritional Sciences, Cornell University, Ithaca, New York (Dr Brenna; jtb4@cornell.edu).

JAMA. 2013;309(1):27. doi:10.1001/jama.2012.116648

To the Editor: The meta-analysis on omega-3 PUFAs and major cardiovascular disease end points concluded that supplementation was not associated with lower risk of cardiovascular disease events.1 Such a conclusion, based on a summary statistical analysis of highly variable treatments, conflates specific drug therapies with the nutrients that supplements are intended to deliver.

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