A team led by scientists in Denmark has genetically engineered a pig model for atherosclerosis that develops severe hypercholesterolemia and human-like progressive atherosclerotic lesions (Al-Mashhadi RH et al. Sci Transl Med. 2013;5:166ra1). The accomplishment is significant because normal pigs have a low propensity to develop atherosclerosis even with prolonged high-fat, high-cholesterol diets.
Hampton T. High-Cholesterol Pigs. JAMA. 2013;309(5):431-431. doi:10.1001/jama.2013.54