Letters Section Editor: Jody W. Zylke, MD, Senior Editor.
Author Affiliation: Department of Critical Care Medicine, Jinhua Municipal Central Hospital, Jinhua, China (email@example.com).
To the Editor: Dr Serpa Neto and colleagues1 addressed the issue of whether the use of protective ventilation would be associated with a benefit in patients without acute respiratory distress syndrome (ARDS). However, this review was not without limitations, including the phenomenon in meta-analyses termed small study effects. Small study effects refer to the fact that small trials are more likely to report beneficial effects in the intervention group.2
Zhang Z. Protective Ventilation for Patients Without Acute Respiratory Distress Syndrome. JAMA. 2013;309(7):654. doi:10.1001/jama.2012.197014